Google Scholar: https://scholar.google.com/citations?user=1zZ54fcAAAAJ&hl=en
Complete List of Published Work in NCBI MyBibliography http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/41146544/?sort=date&direction=ascending
Chaib M, Holt JR, Fisher EL, Sipe LM, Bohm MS, Joseph SC, Simmons BS, Eugin Simon S, Yarbro JR, Tanveer U, Halle JL, Carson JA, Hollingsworth TJ, Wei Q, Rathmell JC, Thomas PG, Hayes DN, Makowski L. (2022). Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer. Science Advances 2023 Dec 22;9(51):eadd3231. Epub 2023 Dec 22. PMID: 38134280; PMCID: PMC10745701. LINK
Asemota S. Effah W, Young KL, Holt J, Cripe L, Ponnusamy S, Thiyagarajan T, Hwang D-J, He Y, McNamara K, Johnson D, Wang Y, Grimes B, Khosrosereshki Y, Hollingsworth TJ, Fleming MD, Pritchard FE, Hendrix A, Khan F, Fan M, Makowski L, Yin Z, Sasano H, Hayes DN, Pfeffer LM, Miller DD, Narayanan R. Identification of a Targetable JAK-STAT Enriched Androgen Receptor (AR) and AR Splice Variant Positive Triple Negative Breast Cancer Subtype. Cell Reports 2023 Nov 17;42(12):113461. doi: 10.1016/j.celrep.2023.113461. Online ahead of print. PMID: 37979170 LINK
Xu F, Ziebarth JD, Goeminne LJ, Gao J, Williams EG, Quarles LD, Makowski L, Cui Y, Williams RW, Auwerx J, Lu L. Gene Network Based Analysis Identifies a Co-expression Module Involved in Plasma Lipid Metabolism with High Fat Diet Response. J Nutr Biochem 2023 Sep;119:109398 Epub 2023 Jun 10. PMID: 37302664 LINK
Chaib M#, Hafeez BB, Mandil H, Daria D, Pingili AK#, Kumari S, Sikander M, Kashyap VK, Chen GY, Anning E, Tripathi MK, Khan S, Behrman S, Yallapu MM, Jaggi M, Makowski L, Chauhan SC. Reprogramming of pancreatic adenocarcinoma immunosurveillance by a microbial probiotic siderophore. Commun Biol 5, 1181 (2022). PMID: 36333531. PMCID: PMC9636404. LINK
Bohm MS, Sipe LM, Pye ME, Davis MJ, Pierre JF, Makowski L. The role of obesity and bariatric surgery-induced weight loss in breast cancer. Cancer Metastasis Rev. 2022 Sep;41(3):673-695. Epub 2022 Jul 23. PMID: 35870055 LINK
Chaib M, Tanveer UA, Makowski L. Myeloid Cells in the Era of Cancer Immunotherapy: Top 3 Unanswered Questions. Pharmacology & Therapeutics, 2023, 108370, ISSN 0163-7258. 2023. PMID: 36871784 LINK
Sipe LM#, Chaib M#, Korba EB#, Jo H, Lovely MC#, Counts BR, Tanveer U, Jolt JR, Clements JC#, John NA#, Daria D, Marion TN, Bohm MS#, Sekhri R, Pingili AK, Teng B, Carson JA, Hayes DN, Davis MJ, Cook KL, Pierre JF, Makowski Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery. 2022 Apr. BioRxiv. LINK. Elife. 2022 Jul 1;11:e79143. PMID: 35775614. LINK
Cutting the risk of cancer – ELife Digest commentary about Sipe et al. Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery. Elife. 2022 LINK
Patel PS, Castelow C, Patel DS, Bhattacharya SK, Kuscu C, Kuscu C, Makowski L, Eason JD, Bajwa A. Mitochondrial Role in Oncogenesis and Potential Chemotherapeutic Strategy of Mitochondrial Infusion in Breast Cancer. Int J Mol Sci. 2022 Oct 27;23(21):12993. PMID: 36361782 LINK
Chaib M#, Sipe LM#, Yarbro JR, Bohm MS#, Counts BR, Tanveer U, Pingili AK, Daria D, Marion TN, Carson JA, Thomas PG, Makowski L. PKC Agonism Restricts Innate Immune Suppression, Promotes Antigen Cross-Presentation and Synergizes with Agonistic CD40 Antibody Therapy to Activate CD8+ T cells in Breast Cancer. Cancer Lett. 2022 Jan 21;531:98-108. PMID: 35074498. LINK
Rana M, Kansal R, Chaib M, Teng B, Morrrison M, Hayes DN, Stanfill AG, Shibata D, Carson JA, Makowski L, Glazer ES. The pancreatic cancer immune tumor microenvironment is negatively remodeled by gemcitabine while TGF-β receptor plus dual checkpoint inhibition maintains antitumor immune cells. Mol Carcinog. 2022 Jun;61(6):549-557. Epub 2022 Mar 23. PMID: 35319799. LINK
Meena AS, Shukla PK, Bell B, Giorgianni F, Caires R, Fernández-Peña C, Beranova S, Aihara E, Montrose MH, Chaib M, Makowski L, Neeli I, Radic MZ, Vásquez V, Jaggar JH, Cordero-Morales JF, Rao R. TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response. Cell Rep. 2022 Jun 14;39(11):110937. PMID: 35705057 LINK
Cell Rep. 2021 Jun 22;35(12):109285. PMID: 34161764 LINK
Gene-by-environmental modulation of longevity and weight gain in the murine BXD family. BioRxiv. LINK Nat Metab. 2021 Sep;3(9):1217-1227. Epub 2021 Sep 22. PMID: 34552269. PMC8478125. LINK
J Gastrointest Surg. 2021 Jul 14. PMID: 34260016 LINK
Hussain, SM, Kansal, RG, Alvarez MA, Hollingsworth TJ, Elahi A, Mirando-Carboni G, Hendrick LE, Pingili AK, Albritton LM, Dickson PV, Deneve JL, Yakoub D, Hayes DN, Kurosu M, Shibata D, Makowski L, Glazer ES. Role of TGF-β in pancreatic ductal adenocarcinoma progression and PD-L1 expression . 2021 Mar. PMID: 33694102 LINK
Flynn MC, Kraakman MJ, Tikellis C, Lee MK, Hanssen NM, Kammoun HL, Pickering R, Dragoljevic D, Al-Sharea A, Barrett TJ, Hortle F, Byrne FL, Olzomer E, McCarthy DA, Schalkwijk CG, Forbes JM, Hoehn K, Makowski L, Lancaster GI, El-Osta A, Fisher EA, Goldberg IJ, Cooper ME, Nagareddy PR, Thomas MC, Murphy AJ. Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis. Circ Res. 2020 Jun 22. PMID: 32564710 LINK
Rousselle T, Kuscu C, Kuscu C, Schlegel K, Huang L, Eason J, Makowski L, Maluf D, Mas V, and Bajwa A. FTY720 Regulates Mitochondria Biogenesis in Dendritic Cells to Prevent Kidney Ischemic Reperfusion Injury. Frontiers in Immunology 2020 Jun 23;11:1278. PMID: 32670281 PMCID: PMC7328774 LINK
Bowman BM, Montgomery SA, Schrank TP, Simon JM, Ptacek TS, Tamir TY, Muvlaney KM, Weir SJ, Nguyen TT, Murphy RM, Makowski L, Hayes DN, Chen XL, Randell SH, Weissman BE, Major MB. A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue. The Journal of Pathology. J Pathol. 2020 Jul 3. PMID: 32619021 LINK
Sipe LM*, Chaib M*, Pingili AK, Pierre JF, Makowski L. Microbiome, Bile Acids, and Obesity: how microbially modified metabolites shape anti-tumor immunity. Immunological Reviews. 2020 May;295(1):220-239. PMID32320071. LINK
Makowski L, Chaib M, Rathmell JC. Immunometabolism: From Basic Mechanisms to Translation. 2020. Immunological Reviews. 2020 May;295(1):5-14. PMID: 32320073 LINK
#Chaib M, Chauhan SC, Makowski L. Friend or Foe? Recent strategies to target myeloid cells in cancer. Cell Dev. Biol. 19 May 2020. PMC7249856. LINK
Smith, A, Pierre JF, Makowski L, Tolley E, Lyn-Cook B, Lu L, Vidal G, Starlard-Davenport A. Distinct microbial communities that differ by race, stage, or breast tumor subtype in breast tissues from African American and European American women, Scientific Reports. 2019;9(1):11940 PMC6697683 LINK
Freemerman AJ*, Zhao L*^, Pingili AK, Teng B, Cozzo AJ^, Fuller AM^, Johnson AR^, Milner JJ^, Lim MF^, Galanko JA, Beck MA, Bear JE, Rotty JD, Brezavada L, Smallwood HS, Puchowicz MA, Liu J, Locasale J, Lee DP, Bennett BJ, Abel ED, Rathmell JC, Makowski L. GLUT1-deficient reprogramming of macrophage immunometabolism in obese adipose and atherosclerotic lesions. J Immunol. 2019 Feb 15;202(4):1265-1286 PMID: 30659108. LINK
Morioka S, Perry JSA, Raymond MH, Medina CB, Zhu Y, #Zhao L, Serbulea V, Onengut-Gumuscu S, Leitinger N, Kucenas S, Rathmell JC, Makowski L, and Ravichandran KS. Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. Nature, 2018 Nov;563(7733):714-718. 2018. PMID:30464343. PMCID: PMC6331005 LINK
Guo H, Kong W, Zhang L, Han J, Clark LH, Yin Y, Fang Z, Sun W, Wang J, Gilliam TP, Lee D, Makowski L, Zhou C, Bae-Jump VL. Reversal of obesity-driven aggressiveness of endometrial cancer by metformin. Am J Cancer Res. 2019. PMID: 31720081. LINK
Porrello A, Leslie PL, Harrison EB, Gorentla BK, Kattula S, Ghosh SK, Azam SH, Holtzhausen A, Chao YL, Hayward MC, Waugh TA, Bae S, Godfrey V, Randell SH, Oderup C, Makowski L, Weiss J, Wilkerson MD, Hayes DN, Earp HS, Baldwin AS, Wolberg AS, Pecot CV. Factor XIIIA-Expressing Inflammatory Monocytes Promote Lung Squamous Cancer through Fibrin Cross-Linking. Nature Communications, 2018. LINK
Zhao L^, Cozzo AJ^, Johnson AR^, Christensen T^, Freemerman AJ, Bear JE, Rotty JD, Bennett BJ, Makowski L. Lack of Macrophage FATP1 Increases Atherosclerotic Lesion Size in Ldlr-/- Atherosclerosis, 2017 Nov;266:182-189. PMID: 29035781 (p 1-7). 2017. LINK
Han JJ, Wysham W, Zhong Y, Guo H, Zhang L, Malloy K, Dickens H, Huh G, Lee D, Makowski L, Zhou C, Bae-Jump VL. Increased efficacy of metformin corresponds to differential metabolic effects in the ovarian tumors from obese versus lean mice. 2017 Dec 19; 8(67): 110965–110982. PMID: 29340030 PMCID: PMC5762298 (p.1-18). LINK
Allicock M, Graves N, Gray K, Makowski L, Allport AH, Freeman K. Troester M. What Health Care Providers Know and How They Communicate Breast Cancer Risk to Patients. Medical Research Archives. 5, n. 7, 2017. (p. 1-14). LINK
Fishbein L, Leshchiner I, Walter V, Danilova L, Robertson AG, Johnson AR, Lichtenberg TM, Murray BA, Ghayee HK, Else T, Ling S, Jefferys SR, de Cubas AA, Wenz B, Korpershoek E, Amelio AL, Makowski L, Rathmell WK, Gimenez-Roque AP, Giordano TJ, Asa SL, Tischler AS; Cancer Genome Atlas Research Network., Pacak K, Nathanson KL, Wilkerson MD. Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma. Cancer Cell. 2017. PMID: 28162975 (p 1-18). LINK
Roque DR, Makowski L, Chen T-H, Rashid N, Hayes DN, Bae-Jump V. Association between differential gene expression and body mass index among endometrial cancers from The Cancer Genome Atlas Project. Gynecol Oncol. 2016 Aug;142(2):317-22. Epub 2016 Jun 14. PMID:27288544. (p. 1-18) LINK
Lengyel E, Makowski L, DiGiovanni, J, Kolonin MG. Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors. Trends in Cancer. May 2018 (p.374-384). LINK
Torres AM, Makowski L, Wellen KE. Metabolism fine-tunes macrophage activation. eLife 2016 Feb 19;5. pii: e14354. doi: 10.7554/eLife.14354. PMID: 26894957.(commentary) (p. 1-2). LINK
Cozzo AJ and Makowski L. Contribution of adipose tissue to development of cancer. Comprehensive Physiology, the new title for the update to APS’s Handbooks of Physiology. 2017 Dec 12;8(1):237-282. PMID: 29357128. (p. 1-45).
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Johnson AR*, Qin YY*, Cozzo A, Freemerman AJ, Huang MJ, Zhao L, Sampey BP, Milner JJ, Beck MA, Edin ML, Zeldin D, Galanko JA, Lee D, Fueger PT, Damania B, Bivins B, Stahl A, Wu Y, Mohlke K, Makowski L. Macrophage Fatty Acid Transporter 1 (FATP1) Drives Alternative Macrophage Polarization and Limits Obesity-Induced Inflammation. *denotes co-first authorship. Molecular Metabolism, 10-MAY-2016 DOI information: 10.1016/j.molmet.2016.04.005 LINK
Amy R Johnson; Matthew D Wilkerson; Brante P Sampey; Melissa A Troester; D. Neil Hayes; Liza Makowski “Cafeteria Diet-induced Obesity Causes Oxidative Damage in White Adipose”Biochemical and Biophysical Research Communications LINK
Alyssa Joy Cozzo; Sneha Sundaram; Ottavia Zattra; Yuanyuan Qin; Alex J Freemerman; Luma Essaid; David B Darr; Stephanie A Montgomery; Kirk K McNaughton; J. Ashley Ezzell; Joseph A Galanko; Melissa A Troester; Liza Makowski, Ph.D. “cMET inhibitor crizotinib impairs angiogenesis and reduces tumor burden in the C3(1)-Tag model of basal-like breast cancer” LINK
Yuanyuan Qin; Sneha Sundaram; Luma Essaid; Xin Chen; Samantha Marie Miller; Feng Yan; David Brian Darr; Joseph A. Galanko; Stephanie A Montgomery; Michael Ben Major; Gary L Johnson; Melissa A Troester; Liza Makowski “Weight loss reduces basal-like breast cancer through kinome reprogramming” Cancer Cell International LINK
Drs. Victoria Bae-Jump (associate Professor OB/GYN) and Liza Makowski (assistant professor, Nutrition) have just published a manuscript entitled “Obesity increases tumor aggressiveness in a genetically engineered mouse model of serous ovarian cancer” in a special issue of Gynecologic Oncology entitled, “The Obesity Crisis: Impact of Gynecologic Cancer.” The project was funded by UNC funds (UCRF, NORC and NCTracs), as well as DOD, and NIH, among others.
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Freemerman AJ, Johnson AR, Sacks GN, Milner JJ, Kirk EL, Troester MA, Macintyre AN, Goraksha-Hicks P, Rathmell JC, Makowski L. Metabolic reprogramming of macrophages: Glucose Transporter (GLUT1)-mediated glucose metabolism drives a pro- inflammatory phenotype. J Biol Chem. 2014 Feb 3. [Epub ahead of print] PMID 24492615 2014.
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Sundaram S, Freemerman AJ, Johnson AR, Milner JJ, McNaughton KK, Galanko JA, Bendt KM, Darr DB, Perou CM, Troester MA, Makowski L. Role of HGF in obesity-associated tumorigenesis: C3(1)-TAg mice as a model for human basal-like breast cancer. Breast Cancer Res Treat. 2013 Nov 12.
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Sundaram S, Johnson AJ, Makowski L Obesity, metabolism and the microenvironment: Links to cancer.
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Bhatt AP, Jacobs SR, Freemerman AJ, Makowski L, Rathmell JC, Dittmer DP, and Damania B. Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma. Proc Natl Acad Sci USA. Jul 17;109(29):11818-23. Epub 2012 Jun 29. PMID: 22752304
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Sampey BP, Freemerman AJ, Zhang J, Kuan PF, Galanko JA, O’Connell TM, Ilkayeva OR, Muehlbauer MJ, Stevens RD, Newgard CB, Brauer HA, Troester MA, Makowski L. Metabolomic Profiling Reveals Mitochondrial-Derived Lipid Biomarkers that Drive Obesity-Associated Inflammation. PLoS One. 2012;7(6):e38812. Epub 2012 Jun 12. PMID: 22701716
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Stewart DA, Yang Y, Makowski L, Troester MA. Basal-like breast cancer cells induce phenotypic and genomic changes in macrophages in vitro. Molecular Cancer Research. 2012 Jun;10(6):727-738. Epub 2012 Apr 24. PMID: 22532586 2012.
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Sun X, Casbas-Hernandez P, Bigelow C, Makowski L, Jerry DJ, Schneider SS, Troester MA. Normal Breast Tissue of Obese Women is Enriched For Macrophage Markers And Macrophage-Associated Gene Expression. Breast Cancer Res Treat. 2011 Oct 15. [Epub ahead of print] PMID:22002519
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Ang MK, Patel MR, Yin X, Sundaram S, Fritchie K, Zhao N, Liu Y, Freemerman AJ, Wilkerson MD, Walter V, Weissler MC, Shockley WW, Couch ME, Zanation AM, Hackman TG, Chera BS, Harris SL, Miller CR, Thorne L, Hayward MC, Funkhouser W, Olshan AF, Shores CG, Makowski L, Hayes DN. High XRCC1-protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma. Clin Cancer Res. 2011 Oct 15;17(20):6542-6552. Epub 2011 Sep 9.PMID:21908577
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Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Sampey BP, Vanhoose AM, Winfield HM, Freemerman AJ, Muehlbauer MJ, Fueger PT, Newgard CB, Makowski L. Obesity (Silver Spring). 2011 Jun;19(6):1109-17. Epub 2011 Feb 17. PMID:21331068
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Genistein effects on stromal cells determines epithelial proliferation in endometrial co-cultures. Sampey BP, Lewis TD, Barbier CS, Makowski L, Kaufman DG. Exp Mol Pathol. 2011 Jun;90(3):257-63. Epub 2011 Jan 31. PMID:21281625
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Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow ME, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS. Nat Med. 2009 Dec;15(12):1383-91. Epub 2009 Nov 29. Erratum in: Nat Med. 2010 Feb;16(2):237. PMID:19966778
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Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. Makowski L, Noland RC, Koves TR, Xing W, Ilkayeva OR, Muehlbauer MJ, Stevens RD, Muoio DM. FASEB J. 2009 Feb;23(2):586-604. Epub 2008 Oct 22. PMID:18945875
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Role of LKB1 in lung cancer development. Makowski L, Hayes DN. Br J Cancer. 2008 Sep 2;99(5):683-8. Epub 2008 Aug 19. Review. PMID:18728656
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Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Nature. 2007 Jun 21;447(7147):959-65. Epub 2007 Jun 6. PMID:17554340
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Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Brüning JC. Cell Metab. 2006 Apr;3(4):247-56. Erratum in: Cell Metab. 2006 Jun;3(6):469. Tobe, Kazuyuki [added]; Kadowaki, Takashi [added]. PMID:16581002
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The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. Makowski L, Hotamisligil GS. Curr Opin Lipidol. 2005 Oct;16(5):543-8. Review. PMID:16148539
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The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS. J Biol Chem. 2005 Apr 1;280(13):12888-95. Epub 2005 Jan 31. PMID:15684432
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Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Circulation. 2004 Sep 14;110(11):1492-8. Epub 2004 Sep 7. PMID:15353487
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Fatty acid binding proteins–the evolutionary crossroads of inflammatory and metabolic responses. Makowski L, Hotamisligil GS. J Nutr. 2004 Sep;134(9):2464S-2468S. Review. PMID:15333743
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Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Maeda K, Uysal KT, Makowski L, Görgün CZ, Atsumi G, Parker RA, Brüning J, Hertzel AV, Bernlohr DA, Hotamisligil GS. Diabetes. 2003 Feb;52(2):300-7. PMID:12540600
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Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1686-91. PMID:12377750
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Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF.Nat Med. 2001 Jun;7(6):699-705. PMID:11385507
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Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice. Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA, Hotamisligil GS. Diabetes. 1999 Oct;48(10):1987-94. PMID:10512363
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Stability of human plasma leptin concentrations within 36 hours following specimen collection. Chu NF, Makowski L, Hotamisligil GS, Rimm EB. Clin Biochem. 1999 Feb;32(1):87-9. No abstract available. PMID:10074899
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