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We are hiring for our newly funded NCI U01 to study obesity, protective immunity, and breast cancer risk.

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Come work with us! Link to posting here.

We can’t wait to work with NCI’s Metabolic Dysregulation and Cancer Risk Program: A Transdisciplinary Approach to Obesity-Associated Cancer Research program.

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Very excited to conduct this work on my project entitled Determining the Contribution of Microbial-Derived Metabolites to Protective Immunity in Obesity-Driven Cancer Risk with MPIs Jeff Rathmell and Joseph Pierre, and many other collaborators. This is a dream project! These studies will increase understanding of obesity-associated cancer risk and point to potential interventions to alleviate… Read More

Check out our new paper led by Dr. Laura Sipe, PhD in eLife on immunotherapy response in pre-clinical models of breast cancer after bariatric surgery

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Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery. Link HERE

Happy Graduation to Dr. Mehdi Chaib, PhD – Commencement 2022

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Mehdi Chaib, PhD (@ChaibImmune) has completed his doctoral studies in the Makowski lab and has joined the lab of Jim Allison, PhD at MD Anderson to complete his post-doctoral studies.

UTHSC-led team receives $5.2 million for study of link between obesity – Press release from UTHSC for our new U01 grant!

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Congratulations to Dr. Mehdi Chaib, Ph.D.

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5/11/2022- Mehdi Chaib successfully defended his thesis entitled “Targeting Myeloid Protein Kinase C Signaling to Overcome Immune Suppression and Improve Immunotherapy in Cancer”. We can’t wait to see you walk in August!

Press release is out for our new R01 to study breast cancer genetics

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UTHSC Team Receives $2 Million For Breast Cancer Genetics Research

Makowski lab receives R01 from NCI to study genetic variants in breast cancer.

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We are happy to announce that Liza Makowski was awarded an R01 from the NCI which scored a 2%. The proposal is entitled “Determining susceptibility loci in triple negative breast cancer using a novel pre-clinical model.” Co-investigators Drs. Rob Williams, Lu Lu, D. Neil Hayes, and David Ashbrook at UTHSC and Dr. Carey Anders at… Read More

Mehdi Chaib awarded F31NRSA Pre-doctoral Fellowship award from the National Cancer Institute (NCI)

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Mehdi Chaib, graduate student in Makowski Lab, was awarded a 3 year F31 predoctoral NRSA fellowship from the NCI in Dec of 2021. His proposal entitled “PKC agonism restricts innate immune suppression and promotes antigen cross-presentation in Triple Negative Breast Cancer” scored a 3%. We are so proud of him! Congratulations!

Excited to share our new manuscript led by Mehdi Chaib in Cancer Letters on PKC agonism

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Makowski lab graduate student Mehdi Chaib has published “PKC agonism restricts innate immune suppression, promotes antigen cross-presentation and synergizes with agonistic CD40 antibody therapy to activate CD8 + T cells in breast cancer” in Cancer Letters (here). Congratulations Mehdi! Highlights: •PKC agonism suppresses murine breast cancer tumor growth in vivo. •PKC agonism impairs MDSC expansion, trafficking, and suppressive… Read More